Terms of Use. Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. In These drugs include some antidepressants; calcium channel blockers; and cardiac, HIV, and anti-seizure medications. Grapefruit products, including grapefruit … 7 Potential Side Effects of Albuterol Inhalers like ProAir, Ventolin, and Proventil, These 10 Prescription and OTC Medications Can Cause Heartburn and Hurt Your Esophagus. All trademarks, brands, logos and copyright images are property Cookie Preferences Has your provider ever warned you not to eat grapefruit if you take statins to treat high cholesterol? People taking statins should not ingest grapefruit. If the body can't properly metabolize cholesterol-lowering drugs, the drugs can build up in the patient's system, resulting in an overdose. Interestingly, the interaction between grapefruit … drug, pharmacy or other information on the site. Not all statins have the same dangerous interaction with grapefruits. The metabolism of some cholesterol drugs, such as pravastatin (Pravachol ®), fluvastatin (Lescol ®), and pitavastatin (Livalo ®), doesn't seem to be affected by grapefruit in the same way as other statin drugs. In all states except Tennessee, GoodRx is considered a marketer of prescription FDA Approves Remdesivir (Veklury) to Treat COVID-19. Grapefruit juice contains compounds called furanocoumarins that … The trouble only occurs with atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor). Grapefruit can inhibit an enzyme in your liver that is needed to metabolize (breakdown) statins. Statins and grapefruit are not the only significant drug/fruit interaction of which you need to be aware. Our livers contain enzymes that break down chemicals and medications, so they can be eliminated from the body. Coincidentally, the enzymes that break down some statins also interact with chemicals in grapefruits. If you take statin drugs for lowering cholesterol, it is a good idea to avoid grapefruit and grapefruit products. A: Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream. When this happens, it can cause unpleasant and even harmful side effects like muscle pain (also known as myopathy). Q. I love grapefruit, the whole fruit. How about mixing pravastatin and vitamin C supplement? Should patients avoid grapefruit juice consumption while taking widely used statins? What Are the Differences between Simvastatin and Lovastatin? Seville oranges are often included in fruit compotes and marmalades, and pomelos, or Chinese grapefruit, are a citrus fruit from southeast Asia that can be found in ethnic markets. If that enzyme is inhibited, the statin drugs stick around longer in your system and can cause more side effects and puts you … Statin drugs, also known as HMG-CoA reductase inhibitors, work by blocking the enzyme that your body needs to produce cholesterol. discount cards, and is not required to register as a discount card provider. What Are the Differences between Atorvastatin and Simvastatin Treatments. of their respective owners and rights holders and are used solely to represent the products GoodRx is not sponsored by or affiliated with any of the pharmacies identified in When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects. However, this is no problem for me. In essence, grapefruit chemicals can attach to liver enzymes and affect how those enzymes process medications. Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage. Why Do I Need Folic Acid When I’m Taking Methotrexate? any of the pricing data or other information. GoodRx is not offering advice, recommending or endorsing any specific prescription Still, some medical professionals advise caution when combining the two anyway, and suggest that patients delay grapefruit consumption for several hours after taking their medication. In the case of certain statins, grapefruit … Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage. It is understandable that those who take statin drugs might want to add fresh grapefruit or grapefruit juice to their diets.